Focus on Plantago species used in human affections with a base of pain or inflammation


Fons Françoise, Faculté de Pharmacie Université de Montpellier, UMR 5175 CEFE, Professeur, France,
Weber Ravn Helle, Krusaavej 3, DK-8600 Silkeborg, Dept. of Research & Development, Chercheur, Denmark,
Rapior Sylvie, Faculté de Pharmacie Université de Montpellier, UMR 5175 CEFE, Professeur, France,

About two hundred Plantago species are worldwide distributed. Several Plantago species, i.e., P. asiatica, P. lanceolata, P. major and P. ovata are well-known as antibacterial, anti-inflammatory, antioxidant [1]. Indeed, they are used in traditional medicines as intestinal transit regulators, insect bites, eye irritation, for wound healing property as well as to relieve pain or to act on inflammatory symptoms in several chronic diseases (irritable bowel syndrome, chronic bronchitis…). Seeds of several species produce mucilage which explains both traditional and current uses as natural laxative agent based on changes in the intestinal resorption of lipids and sugars [2]. Leaves of Plantago species produce iridoids, phenolic compounds and cinnamic acid derivatives [3]; these bioactive molecules from plantains extracts are used in the treatment of eye pathologies or respiratory tract diseases. In the present work [4-5], we evaluate and discuss on Plantago species uses to prevent or treat human affections with a base of pain or inflammation comparing various experimental approaches (in vitro, in vivo, clinical trials).

1- Fons F., Gargadennec A., Rapior S. Culture of Plantago species as bioactive components resources: a 20-year review and
recent applications. Acta Bot. Gallica 2008; 15(2), 277-300.
2- Sarfraz R.M., Khan H., et al. Plantago ovata: a comprehensive review on cultivation, biochemical, pharmaceutical and
pharmacological aspects. Acta Pol. Pharm. 2017; 74(3), 739-746.
3- Ravn H., Nishibea S., et al. Phenolic compounds from Plantago asiatica. 1989; 29(11), 3627-3631.
4- Fernández-Bañares F., Hinojosa J., et al. Randomized clinical trial of Plantago ovata seeds as compared with mesalamine in
maintaining remission in ulcerative colitis. Spanish Group for the Study of Crohn’s Disease and Ulcerative Colitis. Am. J.
Gastroenterol. 1999; 94(2), 427-433.
5- Núñez Guillén M.E., da Silva Emim J.A., et al. Analgesic and anti-inflammatory activities of the aqueous extract of Plantago
major L. Int. J. Pharmacognosy 1997; 35(2), 99-104.

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